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Decreased intranuclear cardiac troponin I impairs cardiac autophagy through FOS / ATG5 in ageing hearts

29 Apr 2024

Abstract excerpt

In our previous study, intranuclear cardiac troponin I (cTnI) may function as a co-factor of Yin Yang 1(YY1). Here, we aimed to explore the role of intranuclear cTnI in ageing hearts. Nuclear translocation of cTnI was demonstrated using Western blot and immunofluorescence. The potential nuclear localization sequences (NLSs) of cTnI were predicted by a web server and then verified in 293T cells by putative...

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PMID: 38683127
DOI: 10.1111/jcmm.18357

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