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Article

NFAT transcription factor regulation by urocortin II in cardiac myocytes and heart failure

18 Jan 2014

Abstract excerpt

Urocortin II (UcnII), a cardioactive peptide with beneficial effects in normal and failing hearts, is also arrhythmogenic and prohypertrophic. We demonstrated that cardiac effects are mediated by a phosphatidylinositol-3 kinase (PI3K)/Akt kinase (Akt)/endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) signaling pathways. Nuclear factor of activated T-cells (NFAT) transcription factors play a key role in...

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PMID: 24441548
DOI: 10.1152/ajpheart.00353.2013

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