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Influence of MTHFR C677T Polymorphism on High-Dose Methotrexate-Related Toxicity in Patients With Primary Central Nervous System Diffuse Large B-Cell Lymphoma.

Clinical lymphoma, myeloma & leukemia - 1 Feb 2021

Chang Xiaoli, Guo Yixian, Su Li, Zhang Yunxiu, Hui Wuhan, Zhao Hong, Hu Ronghua, Sun Wanling

Abstract excerpt

BACKGROUND: Primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) is a relatively rare and aggressive neoplasm. High-dose methotrexate (HD-MTX) is an effective regimen for the treatment of PCNS-DLBCL, but MTX-related toxicity remains a problem. The aim of this analysis study was to investigate the influence of the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism on...

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Identifiers

PMID: 33069634
DOI: 10.1016/j.clml.2020.08.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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