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Article

Shared molecular mechanisms and transdiagnostic potential of neurodevelopmental disorders and immune disorders.

Brain, behavior, and immunity - 1 Jul 2024

Xiu Zhanjie, Sun Ling, Liu Kunlun, Cao Haiyan, Qu Hui-Qi, Glessner Joseph T, Ding Zhiyong, Zheng Gang, Wang Nan, Xia Qianghua, Li Jie, Li Mulin Jun, Hakonarson Hakon, Liu Wei, Li Jin

Abstract excerpt

The co-occurrence and familial clustering of neurodevelopmental disorders and immune disorders suggest shared genetic risk factors. Based on genome-wide association summary statistics from five neurodevelopmental disorders and four immune disorders, we conducted genome-wide, local genetic correlation and polygenic overlap analysis. We further performed a cross-trait GWAS meta-analysis. Pleotropic loci shared...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38677625
DOI: 10.1016/j.bbi.2024.04.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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