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Article

Role of G326 in Determining the Aggregation Propensity of R3 Tau Repeat: Insights from Studies on R1R3 Tau Construct.

The journal of physical chemistry. B - 9 May 2024

Sahayaraj Allwin Ebenezer, Abdul Vahid Arshad, Dhara Asmita, Babu Ann Teres, Vijayan Vinesh

Abstract excerpt

The Microtubule-binding repeat region (MTBR) of Tau has been studied extensively due to its pathological implications in neurodegenerative diseases like Alzheimer's disease. The pathological property of MTBR is mainly due to the R3 repeat's high propensity for self-aggregation, highlighting the critical molecular grammar of the repeat. Utilizing the R1R3 construct (WT) and its G326E mutant (EE), we determine the...

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Identifiers

PMID: 38676652
DOI: 10.1021/acs.jpcb.4c00123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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