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Investigations into modifications of neuromuscular physiology by axonal transport disruptions in <i>Drosophila</i> SOD1 mutants

2020-11-27

Abstract excerpt

<h4>ABSTRACT</h4> The reactive oxygen species (ROS)-scavenging enzyme Cu/Zn superoxide dismutase (SOD1) is an evolutionarily conserved mechanism for the maintenance of oxidative homeostasis, and missense mutations in the human SOD1 gene are associated with the motor neuron degenerative disease amyotrophic lateral sclerosis (ALS). Mutations in the Drosophila melanogaster SOD1 gene ( Sod ) shorten fly lifespan, a...

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Literature Corpus work
f77944af-769c-5e12-aac7-376397b3d142
DOI
10.1101/2020.11.27.399956
Open publication

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Investigations into modifications of neuromuscular physiology by axonal transport disruptions in <i>Drosophila</i> SOD1 mutantsDOI 10.1101/2020.11.27.399956
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