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Article

Phenotypic Insights Into Anti-IgLON5 Disease in IgLON5-Deficient Mice.

Neurology(R) neuroimmunology & neuroinflammation - 1 May 2024

Lee Sin Yi, Shoji Hirotaka, Shimozawa Aki, Aoyagi Hirofumi, Sato Yoshiaki, Tsumagari Kazuya, Terumitsu Mika, Motegi Haruhiko, Okada Kensuke, Sekiguchi Koji, Kuromitsu Junro, Nakahara Jin, Miyakawa Tsuyoshi, Ito Daisuke

Abstract excerpt

BACKGROUND AND OBJECTIVES: Anti-IgLON5 disease is an autoimmune neurodegenerative disorder characterized by various phenotypes, notably sleep and movement disorders and tau pathology. Although the disease is known to be associated with the neuronal cell adhesion protein IgLON5, the physiologic function of IgLON5 remains elusive. There are conflicting views on whether autoantibodies cause loss of function,...

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Identifiers

PMID: 38657185
DOI: 10.1212/NXI.0000000000200234
PMCID: PMC11087031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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