HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease.

doi:10.1093/brain/awae048

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Article

HLA-DQB105 subtypes and not DRB110:01 mediates risk in anti-IgLON5 disease.

Brain : a journal of neurology - 5 Jul 2024

Yogeshwar Selina M, Muñiz-Castrillo Sergio, Sabater Lidia, Peris-Sempere Vicente, Mallajosyula Vamsee, Luo Guo, Yan Han, Yu Eric, Zhang Jing, Lin Ling, Fagundes Bueno Flavia, Ji Xuhuai, Picard Géraldine, Rogemond Véronique, Pinto Anne Laurie, Heidbreder Anna, Höftberger Romana, Graus Francesc, Dalmau Josep, Santamaria Joan, Iranzo Alex, Schreiner Bettina, Giannoccaro Maria Pia, Liguori Rocco, Shimohata Takayoshi, Kimura Akio, Ono Yoya, Binks Sophie, Mariotto Sara, Dinoto Alessandro, Bonello Michael, Hartmann Christian J, Tambasco Nicola, Nigro Pasquale, Prüss Harald, McKeon Andrew, Davis Mark M, Irani Sarosh R, Honnorat Jérôme, Gaig Carles, Finke Carsten, Mignot Emmanuel

Abstract excerpt

Anti-IgLON5 disease is a rare and likely underdiagnosed subtype of autoimmune encephalitis. The disease displays a heterogeneous phenotype that includes sleep, movement and bulbar-associated dysfunction. The presence of IgLON5-antibodies in CSF/serum, together with a strong association with HLA-DRB1*10:01∼DQB1*05:01, supports an autoimmune basis. In this study, a multicentric human leukocyte antigen (HLA) study...

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PMID: 38425314
DOI: 10.1093/brain/awae048
PMCID: PMC11224611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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