Article
Development and validation of a new multiplex panel using SNaPshot-based DIP-TriSNP markers for forensic DNA mixtures.
Electrophoresis - 1 May 2024
Fan Qingwei, Li Ling, Yang Huiling, Xu Dongdong, Wang Yun, Jin Bo, Du Bing
Abstract excerpt
Short tandem repeat analysis is challenging when dealing with unbalanced mixtures in forensic cases due to the presence of stutter peaks and large amplicons. In this research, we propose a novel genetic marker called DIP-TriSNP, which combines deletion/insertion polymorphism (DIP) with tri-allelic single nucleotide polymorphism in less than 230 bp length of human genome. Based on multiplex PCR and SNaPShot, a...
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