Article
Tri-allelic SNP markers enable analysis of mixed and degraded DNA samples.
Forensic science international. Genetics - 1 Sept 2009
Westen Antoinette A, Matai Anuska S, Laros Jeroen F J, Meiland Hugo C, Jasper Mandy, de Leeuw Wiljo J F, de Knijff Peter, Sijen Titia
Abstract excerpt
For the analysis of degraded DNA in disaster victim identification (DVI) and criminal investigations, single nucleotide polymorphisms (SNPs) have been recognized as promising markers mainly because they can be analyzed in short sized amplicons. Most SNPs are bi-allelic and are thereby ineffective to detect mixtures, which may lead to incorrect genotyping. We developed an algorithm to find non-binary (i.e....
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