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PySupercharge: a python algorithm for enabling ABC transporter bacterial secretion of all proteins through amino acid mutation.

Microbial cell factories - 20 Apr 2024

Kim Yerin, Kim Danny, Hieu Nguyen-Mihn, Byun Hyunjong, Ahn Jung Hoon

Abstract excerpt

BACKGROUND: The process of producing proteins in bacterial systems and secreting them through ATP-binding cassette (ABC) transporters is an area that has been actively researched and used due to its high protein production capacity and efficiency. However, some proteins are unable to pass through the ABC transporter after synthesis, a phenomenon we previously determined to be caused by an excessive positive...

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Identifiers

PMID: 38643109
DOI: 10.1186/s12934-024-02342-z
PMCID: PMC11031901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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