Article

A Fit for Purpose Approach to Evaluate Detection of Amino Acid Substitutions in Shotgun Proteomics

2023-08-13

Abstract excerpt

Amino acid substitutions (AAS) change a protein from its genome-expected sequence. Accumulation of substitutions in proteins underlie numerous diseases and antibiotic mechanisms. Accurate global detection of substitutions and their frequencies would help characterize these mechanisms. Measurement of AAS using shotgun proteomics is attractive due to its high sensitivity and untargeted acquisition. However, identify...

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Literature Corpus work: 9d5049bf-6e73-5cb8-a71e-f492091893bd
DOI: 10.1101/2023.08.09.552645

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