Article
SLE-associated risk factors affect DC function.
Immunological reviews - 1 Jan 2016
Son Myoungsun, Kim Sun Jung, Diamond Betty
Abstract excerpt
Numerous risk alleles for systemic lupus erythematosus (SLE) have now been identified. Analysis of the expression of genes with risk alleles in cells of hematopoietic origin demonstrates them to be most abundantly expressed in B cells and dendritic cells (DCs), suggesting that these cell types may be the drivers of the inflammatory changes seen in SLE. DCs are of particular interest as they act to connect the...
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