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Article

Phenotype-Genotype Correlation Applying a Cocktail Approach and an Exome Chip Analysis Reveals Further Variants Contributing to Variation of Drug Metabolism.

Clinical pharmacology and therapeutics - 1 Jul 2024

Böhm Ruwen, Bruckmueller Henrike, Oswald Stefan, Hübenthal Matthias, Kaehler Meike, Ehmke Lena, Höcker Jan, Siegmund Werner, Franke Andre, Cascorbi Ingolf

Abstract excerpt

Although great progress has been made in the fine-tuning of diplotypes, there is still a need to further improve the predictability of individual phenotypes of pharmacogenetically relevant enzymes. The aim of this study was to analyze the additional contribution of sex and variants identified by exome chip analysis to the metabolic ratio of five probe drugs. A cocktail study applying dextromethorphan, losartan,...

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Identifiers

PMID: 38637968
DOI: 10.1002/cpt.3270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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