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Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors

18 Apr 2024

Abstract excerpt

We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the high-throughput drug screening (HTS) and genomic sequencing methods. We examined 9 patient-derived PitNET primary cells in HTS. Based on the screening results, the potential target genes were analyzed with genomic sequencing from a total of 180 PitNETs. We identified and verified one of the most...

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PMID: 38637883
DOI: 10.1186/s40478-024-01775-2

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