Article

Quantifying negative selection in human 3’ UTRs uncovers constrained targets of RNA-binding proteins

2022-12-01

Abstract excerpt

<h4>ABSTRACT</h4> Many non-coding variants associated with phenotypes occur in 3’ untranslated regions (3’ UTRs) and may affect interactions with RNA-binding proteins (RBPs) to regulate post-transcriptional gene expression. However, identifying functional 3’ UTR variants has proven difficult. We used allele frequencies from the Genome Aggregation Database (gnomAD) to identify classes of 3’ UTR variants under stro...

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Literature Corpus work: f7940b98-1309-5dc7-abcb-8ab75ff9dd62
DOI: 10.1101/2022.11.30.518628

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