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A Statistical Method to Estimate the Population-Level Frequencies of <i>Plasmodium falciparum</i> Haplotypes with <i>Pfhrp</i> 2/3 Deletions in the Presence of Mixed-Clone Infections

2026-04-06

Abstract excerpt

<h4>Background</h4> The World Health Organization (WHO) has raised concerns over increasing Pfhrp 2/3 deletions, undermining the sensitivity of Pfhrp 2-based rapid diagnostic tests (RDTs). Close monitoring of the population and a change in diagnostic methods are recommended if the prevalence of parasites with Pfhrp 2/3 deletions exceeds 5%. In high transmission settings, accurate estimates are hampered by the...

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Literature Corpus work
e1bd2bd4-b33f-5696-8d98-f471c8580d48
DOI
10.64898/2026.04.01.715806
Open publication

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A Statistical Method to Estimate the Population-Level Frequencies of <i>Plasmodium falciparum</i> Haplotypes with <i>Pfhrp</i> 2/3 Deletions in the Presence of Mixed-Clone InfectionsDOI 10.64898/2026.04.01.715806
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