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Article

The origins and relatedness structure of mixed infections vary with local prevalence of P. falciparum malaria

12 Jul 2019

Abstract excerpt

with varying levels of relatedness. Yet, how local epidemiology affects the properties of such mixed infections remains unclear. Here, we develop an enhanced method for strain deconvolution from genome sequencing data, which estimates the number of strains, their proportions, identity-by-descent (IBD) profiles and individual haplotypes. Applying it to the Pf3k data set, we find that the rate of mixed infection...

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PMID: 31298657
DOI: 10.7554/elife.40845

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