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Article

Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report.

BMC pediatrics - 21 Jan 2021

Blanchard-Rohner Geraldine, Ragotte Robert J, Junker Anne K, Sharma Mehul, Del Bel Kate L, Lu Henry Y, Erdle Stephanie, Chomyn Alanna, Gill Harinder, Tucker Lori B, Schreiber Richard A, Rozmus Jacob, Biggs Catherine M, Hildebrand Kyla J, Wu John, Stockler-Ipsiroglu Sylvia, Turvey Stuart E

Abstract excerpt

BACKGROUND: KRAS (KRAS proto-oncogene, GTPase; OMIM: 190,070) encodes one of three small guanosine triphosphatase proteins belonging to the RAS family. This group of proteins is responsible for cell proliferation, differentiation and inhibition of apoptosis. Gain-of-function variants in KRAS are commonly found in human cancers. Non-malignant somatic KRAS variants underlie a subset of RAS-associated autoimmune...

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Identifiers

PMID: 33472608
DOI: 10.1186/s12887-021-02508-3
PMCID: PMC7819237

Genes

KRAS

Variants

Provenance

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