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Germline potential should not be overlooked for cancer variants identified in tumour-only somatic mutation testing.

Pathology - 1 Jun 2024

Al-Shinnag Mohammad, Cheong Pak Leng, Goodwin Annabel, Trent Ronald, Yu Bing

Abstract excerpt

DNA sequencing of tumour tissue has become the standard care for many solid cancers because of the option to detect somatic variants that have significant therapeutic, diagnostic and prognostic implications. Variants found within the tumour may be either somatic or germline in origin. Somatic cancer gene panels are developed to detect acquired (somatic) variants that are relevant for therapeutic or molecular...

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PMID: 38627125
DOI: 10.1016/j.pathol.2024.03.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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