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Article

Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA.

JAMA oncology - 1 Jan 2016

Schrader Kasmintan A, Cheng Donavan T, Joseph Vijai, Prasad Meera, Walsh Michael, Zehir Ahmet, Ni Ai, Thomas Tinu, Benayed Ryma, Ashraf Asad, Lincoln Annie, Arcila Maria, Stadler Zsofia, Solit David, Hyman David M, Hyman David, Zhang Liying, Klimstra David, Ladanyi Marc, Offit Kenneth, Berger Michael, Robson Mark

Abstract excerpt

IMPORTANCE: Tumor genetic sequencing identifies potentially targetable genetic alterations with therapeutic implications. Analysis has concentrated on detecting tumor-specific variants, but recognition of germline variants may prove valuable as well. OBJECTIVE: To estimate the burden of germline variants identified through routine clinical tumor sequencing. DESIGN, SETTING, AND PARTICIPANTS: Patients with...

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PMID: 26556299
DOI: 10.1001/jamaoncol.2015.5208
PMCID: PMC5477989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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