Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Incidental Germline Mutations in Patients With Advanced Solid Tumors Who Underwent Cell-Free Circulating Tumor DNA Sequencing

19 Oct 2018

Abstract excerpt

PURPOSE: To determine the potential for detection of incidental germline cancer predisposition mutations through cell-free DNA (cfDNA) analyses in patients who underwent solid tumor somatic mutation evaluation. PATIENTS AND METHODS: Data were evaluated from 10,888 unselected patients with advanced (stage III/IV) cancer who underwent Guardant360 testing between November 2015 and December 2016. The main outcome was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer
Share to Multiple and Secondary Primary Cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30339520
DOI: 10.1200/jco.18.00328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Incidental Germline Mutations in Patients With Advanced Solid Tumors Who Underwent Cell-Free Circulating Tumor DNA SequencingPMID 30339520Read ↗

Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing.Semantic proximity Read ↗

Germline potential should not be overlooked for cancer variants identified in tumour-only somatic mutation testing.Semantic proximity Read ↗

Combining germline, tissue and liquid biopsy analysis by comprehensive genomic profiling to improve the yield of actionable variants in a real-world cancer cohort.Semantic proximity Read ↗

Prevalence of pathogenic germline variants in the circulating tumor DNA testing.Semantic proximity Read ↗

Cancer Genetic Predisposition and Clinical Applications-A Narrative Review on Germline Genetic Testing, High-Risk Cancer Surveillance and Management.Semantic proximity Read ↗

Identification of Germline Cancer Predisposition Variants During Clinical Ctdna TestingSemantic proximity Read ↗

Germline pathogenic variants identification through Comprehensive Cancer Genome ProfilingSemantic proximity Read ↗

Incidental pathogenic germline alterations detected through liquid biopsy in patients with solid tumors: prevalence, clinical utility and implications.Semantic proximity Read ↗

Prevalence of Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines.Semantic proximity Read ↗

The emerging significance of secondary germline testing in cancer genomics.Semantic proximity Read ↗

Germline Findings in Tumor-Only Sequencing: Points to Consider for Clinicians and Laboratories.Semantic proximity Read ↗

Germline sequencing for presumed germline pathogenic variants via tumor-only comprehensive genomic profilingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.