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Article

The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression

1 Jan 2017

Abstract excerpt

The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal levels. To delineate essential and non-essential Mre11 complex functions that are mediated by Nbs1, we used TALEN-based genome editing to derive Nbs1 mutant mice ( Nbs1 mid...

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PMID: 28076792
DOI: 10.1016/j.celrep.2016.12.035

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