Article
Tools for a personalized tacrolimus dose adjustment in the follow-up of renal transplant recipients. Metabolizing phenotype according to CYP3A genetic polymorphisms versus concentration-dose ratio.
Nefrologia - 1 Jan 2000
Vidal-Alabró Anna, Colom Helena, Fontova Pere, Cerezo Gema, Melilli Edoardo, Montero Nuria, Coloma Ana, Manonelles Anna, Favà Alex, Cruzado Josep M, Torras Joan, Grinyó Josep M, Lloberas Nuria
Abstract excerpt
BACKGROUND AND JUSTIFICATION: The strategy of the concentration-dose (C/D) approach and the different profiles of tacrolimus (Tac) according to the cytochrome P450 polymorphisms (CYPs) focus on the metabolism of Tac and are proposed as tools for the follow-up of transplant patients. The objective of this study is to analyse both strategies to confirm whether the stratification of patients according to the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.