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Article

Influence of CYP3A polymorphisms on tacrolimus pharmacokinetics in kidney transplant recipients.

The pharmacogenomics journal - 1 Feb 2021

Hannachi Ibtissem, Chadli Zohra, Kerkeni Emna, Kolsi Abdessalem, Hammouda Mouna, Chaabane Amel, Ben Fredj Nadia, Touitou Yvan, Boughattas Naceur A, Aouam Karim

Abstract excerpt

Tacrolimus is characterized by a highly variable pharmacokinetics (PK) and a small therapeutic window. It is metabolized specifically by the CYP3A isoenzymes. This study aimed to determine, in kidney transplant patients, the influence of different genotypic clusters involving these SNPs CYP3A4*1B, CYP3A4*22, and CYP3A5*3 on Tacrolimus bioavailability during the first (PTP1) and the second (PTP2) posttransplant...

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Share to Cytochrome P-450 CYP3A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 32843687
DOI: 10.1038/s41397-020-00179-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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