Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

scRNAseq and High-Throughput Spatial Analysis of Tumor and Normal Microenvironment in Solid Tumors Reveal a Possible Origin of Circulating Tumor Hybrid Cells

8 Apr 2024

Abstract excerpt

Metastatic cancer is a leading cause of death in cancer patients worldwide. While circulating hybrid cells (CHCs) are implicated in metastatic spread, studies documenting their tissue origin remain sparse, with limited candidate approaches using one-two markers. Utilizing high-throughput single-cell and spatial transcriptomics, we identified tumor hybrid cells (THCs) co-expressing epithelial and macrophage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38611120
DOI: 10.3390/cancers16071444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

scRNAseq and High-Throughput Spatial Analysis of Tumor and Normal Microenvironment in Solid Tumors Reveal a Possible Origin of Circulating Tumor Hybrid CellsPMID 38611120Read ↗

Relevance of Circulating Hybrid Cells as a Non-Invasive Biomarker for Myriad Solid TumorsSemantic proximity Read ↗

Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumorsSemantic proximity Read ↗

Cell fusion reprograms tumor cells and promotes RUNX1-mediated invasion and dissemination in colorectal cancerSemantic proximity Read ↗

You complete me: tumor cell-myeloid cell nuclear fusion as a facilitator of organ-specific metastasisSemantic proximity Read ↗

Pan-cancer classification of single cells in the tumour microenvironmentSemantic proximity Read ↗

Cancer cell-macrophage fusion increases tumor cell heterogeneity and reshapes their microenvironmentSemantic proximity Read ↗

Analysis of uveal melanoma scRNA sequencing data identifies neoplastic-immune hybrid cells that exhibit metastatic potentialSemantic proximity Read ↗

Heterogeneity of Circulating Tumor Cell Neoplastic Subpopulations Outlined by Single-Cell TranscriptomicsSemantic proximity Read ↗

Pan-cancer classification of single cells in the tumour microenvironmentSemantic proximity Read ↗

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.Semantic proximity Read ↗

Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastasesSemantic proximity Read ↗

Single-cell and spatial architecture of primary liver cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.