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Article

DDIT4/REDD1/RTP801 is a novel negative regulator of Schwann cell myelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Sept 2013

Noseda Roberta, Belin Sophie, Piguet Françoise, Vaccari Ilaria, Scarlino Stefania, Brambilla Paola, Martinelli Boneschi Filippo, Feltri Maria Laura, Wrabetz Lawrence, Quattrini Angelo, Feinstein Elena, Huganir Richard L, Bolino Alessandra

Abstract excerpt

Signals that promote myelination must be tightly modulated to adjust myelin thickness to the axonal diameter. In the peripheral nervous system, axonal neuregulin 1 type III promotes myelination by activating erbB2/B3 receptors and the PI3K/AKT/mTOR pathway in Schwann cells. Conversely, PTEN (phosphatase and tensin homolog on chromosome 10) dephosphorylates PtdIns(3,4,5)P3 and negatively regulates the AKT pathway...

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Source

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Identifiers

PMID: 24048858
DOI: 10.1523/JNEUROSCI.2408-13.2013
PMCID: PMC3988321

Genes

DDIT4
DLG1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DDIT4/REDD1/RTP801 is a novel negative regulator of Schwann cell myelination.PMID 24048858Read ↗

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