Screening of Organophosphate Flame Retardants with Placentation-Disrupting Effects in Human Trophoblast Organoid Model and Characterization of Adverse Pregnancy Outcomes in Mice

Abstract excerpt

Background: Abnormal placental development may result in adverse pregnancy outcomes and metabolic diseases in adulthood; however, it remains unknown whether and how xenobiotics affect human placentation. Objectives: This study aimed to screen and identify placentation-disrupting chemicals in commonly used organophosphate flame retardants (OPFRs) and, if identified, to investigate potential adverse effects on...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pregnancy and preeclampsia studies
• Share to Reproductive Biology and Fertility
• Share to Toxic Organic Pollutants Impact