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A maternal ketogenic diet alters oviduct fluid nutrients and embryo histone acetylation in mice

9 Apr 2024

Abstract excerpt

In brief: A ketogenic diet (KD) elevates blood β-hydroxybutyrate to concentrations that are known to perturb the development, metabolism, histone acetylation and viability of preimplantation mouse embryos in culture. This study shows that a maternal KD changes available nutrient levels in the oviduct, leading to altered embryo development and epigenetic state in vivo. Abstract: A ketogenic diet elevates blood...

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PMID: 38593828
DOI: 10.1530/rep-24-0026

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