Article
Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life.
Biochimica et biophysica acta. Molecular basis of disease - 1 Feb 2018
Velazquez Miguel A, Sheth Bhavwanti, Smith Stephanie J, Eckert Judith J, Osmond Clive, Fleming Tom P
Abstract excerpt
Mouse maternal low protein diet exclusively during preimplantation development (Emb-LPD) is sufficient to programme altered growth and cardiovascular dysfunction in offspring. Here, we use an in vitro model comprising preimplantation culture in medium depleted in insulin and branched-chain amino acids (BCAA), two proposed embryo programming inductive factors from Emb-LPD studies, to examine the consequences for...
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