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β-hydroxybutyrate reduces blastocyst viability via trophectoderm-mediated metabolic aberrations in mice

20 Jul 2022

Abstract excerpt

STUDY QUESTION: What is the effect of the ketone β-hydroxybutyrate (βOHB) on preimplantation mouse embryo development, metabolism, epigenetics and post-transfer viability? SUMMARY ANSWER: In vitro βOHB exposure at ketogenic diet (KD)-relevant serum concentrations significantly impaired preimplantation mouse embryo development, induced aberrant glycolytic metabolism and reduced post-transfer fetal viability in a...

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PMID: 35856159
DOI: 10.1093/humrep/deac153

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