Wnt, glucocorticoid and cellular prion protein cooperate to drive a mesenchymal phenotype with poor prognosis in colon cancer.

doi:10.1186/s12967-024-05164-0

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Article

Wnt, glucocorticoid and cellular prion protein cooperate to drive a mesenchymal phenotype with poor prognosis in colon cancer.

Journal of translational medicine - 8 Apr 2024

Mouillet-Richard Sophie, Gougelet Angélique, Passet Bruno, Brochard Camille, Le Corre Delphine, Pitasi Caterina Luana, Joubel Camille, Sroussi Marine, Gallois Claire, Lavergne Julien, Castille Johan, Vilotte Marthe, Daniel-Carlier Nathalie, Pilati Camilla, de Reyniès Aurélien, Djouadi Fatima, Colnot Sabine, André Thierry, Taieb Julien, Vilotte Jean-Luc, Romagnolo Béatrice, Laurent-Puig Pierre

Abstract excerpt

BACKGROUND: The mesenchymal subtype of colorectal cancer (CRC), associated with poor prognosis, is characterized by abundant expression of the cellular prion protein PrPC, which represents a candidate therapeutic target. How PrPC is induced in CRC remains elusive. This study aims to elucidate the signaling pathways governing PrPC expression and to shed light on the gene regulatory networks linked to PrPC....

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Identifiers

PMID: 38589873
DOI: 10.1186/s12967-024-05164-0
PMCID: PMC11003154

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