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EGFR and Prion protein promote signaling via FOXO 3a‐ KLF 5 resulting in clinical resistance to platinum agents in colorectal cancer

27 Nov 2018

Abstract excerpt

Epidermal growth factor receptor (EGFR) supports colorectal cancer progression via oncogenic signaling. Anti‐EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Prion protein has been detected in neuronal cells. We hypothesized that PrPC expression levels may regulate EGFR signaling and that detailed understanding of this signaling pathway...

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PMID: 30478887
DOI: 10.1002/1878-0261.12411

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