Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis.

doi:10.1186/s12872-024-03821-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis.

BMC cardiovascular disorders - 8 Apr 2024

Liu Yang, Chen Yuan, Wei Baozhu, Li Hang, Peng Yuanyuan, Luo Zhi

Abstract excerpt

BACKGROUND: The latest evidence indicates that ATP-binding cassette superfamily G member 2 (ABCG2) is critical in regulating lipid metabolism and mediating statin or cholesterol efflux. This study investigates whether the function variant loss within ABCG2 (rs2231142) impacts lipid levels and statin efficiency. METHODS: PubMed, Cochrane Library, Central, CINAHL, and ClinicalTrials.gov were searched until November...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers

Share to Dyslipidemias

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Lipids

Share to Neoplasm Proteins

Share to Pharmacogenomic Variants

Share to Rosuvastatin Calcium

Source

Open in PubMed Open full text

Identifiers

PMID: 38589776
DOI: 10.1186/s12872-024-03821-2
PMCID: PMC11000409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis.PMID 38589776Read ↗

Effect of ABCG2 c.421 C> A (rs2231142) single nucleotide polymorphisms on the lipid-modulating efficacy of rosuvastatin: a meta-analysis.Semantic proximity Read ↗

Effects of apolipoprotein E and solute carrier organic anion transporter family member 1B1 gene polymorphisms on statin efficacy and safety in dyslipidemic patients.Semantic proximity Read ↗

The frequency of rs2231142 in ABCG2 among Asian subgroups: implications for personalized rosuvastatin dosing.Semantic proximity Read ↗

Associations between four polymorphisms of the SLCO1B1 and effectiveness of the statins: a meta-analysis.Semantic proximity Read ↗

ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin.Semantic proximity Read ↗

The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins.Semantic proximity Read ↗

The frequency of rs2231142 in ABCG2 among Native Hawaiian and Pacific Islander subgroups: implications for personalized rosuvastatin dosing.Semantic proximity Read ↗

Association Between ABCG2 Polymorphism and Statin-Induced Adverse Events: A Meta-Analysis.Semantic proximity Read ↗

The role of common variants of ABCB1 and CYP7A1 genes in serum lipid levels and lipid-lowering efficacy of statin treatment: a meta-analysis.Semantic proximity Read ↗

APOE genotype and the effect of statins on lipid outcomes: A meta-analysis.Semantic proximity Read ↗

APOE genotype and the effect of statins: a systematic review and meta-analysisSemantic proximity Read ↗

Predicted deleterious variants in ABCA1, LPL, LPA and KIF6 are associated with statin response and adverse events in patients with familial hypercholesterolemia and disturb protein structure and stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.