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Article

The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins.

Expert opinion on drug metabolism & toxicology - 1 Jan 2011

Hu Miao, To Kenneth K W, Mak Valiant W L, Tomlinson Brian

Abstract excerpt

IMPORTANCE OF THE FIELD: The ABCG2 efflux transporter is expressed in multiple tissues and plays an important role in the disposition of many statins. The functional 421C>A polymorphism in ABCG2 that reduces transporter activity has been found to be associated with increased systemic exposures to certain statins. AREAS COVERED IN THIS REVIEW: We review and evaluate the associations of the ABCG2 polymorphism on...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Cholesterol, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Interactions

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Randomized Controlled Trials as Topic

Share to Rosuvastatin Calcium

Share to Sulfonamides

Share to Tissue Distribution

Source

Identifiers

PMID: 21091277
DOI: 10.1517/17425255.2011.538383

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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