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Article

Characterizing the Causal Pathway for Genetic Variants Associated with Neurological Phenotypes Using Human Brain-Derived Proteome Data.

American journal of human genetics - 4 Jun 2020

Kibinge Nelson K, Relton Caroline L, Gaunt Tom R, Richardson Tom G

Abstract excerpt

Leveraging high-dimensional molecular datasets can help us develop mechanistic insight into associations between genetic variants and complex traits. In this study, we integrated human proteome data derived from brain tissue to evaluate whether targeted proteins putatively mediate the effects of genetic variants on seven neurological phenotypes (Alzheimer disease, amyotrophic lateral sclerosis, depression,...

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Identifiers

PMID: 32413284
DOI: 10.1016/j.ajhg.2020.04.007
PMCID: PMC7273531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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