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Article

Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status.

PloS one - 1 Jan 2012

An She-Juan, Chen Zhi-Hong, Su Jian, Zhang Xu-Chao, Zhong Wen-Zhao, Yang Jin-Ji, Zhou Qing, Yang Xue-Ning, Huang Ling, Guan Ji-Lin, Nie Qiang, Yan Hong-Hong, Mok Tony S, Wu Yi-Long

Abstract excerpt

BACKGROUND: Appropriate patient selection is needed for targeted therapies that are efficacious only in patients with specific genetic alterations. We aimed to define subgroups of patients with candidate driver genes in patients with non-small cell lung cancer. METHODS: Patients with primary lung cancer who underwent clinical genetic tests at Guangdong General Hospital were enrolled. Driver genes were detected by...

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Identifiers

PMID: 22768234
DOI: 10.1371/journal.pone.0040109
PMCID: PMC3387024

Genes

EGFR
KRAS
PTEN
STK11
ALK
BRAF
DDR2
EML4
FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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