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GADD45g acts as a novel tumor suppressor, and its activation suggests new combination regimens for the treatment of AML.

Blood - 12 Aug 2021

Guo Dan, Zhao Yangyang, Wang Nan, You Na, Zhu Wenqi, Zhang Peiwen, Ren Qian, Yin Jing, Cheng Tao, Ma Xiaotong

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy for which there is an unmet need for novel treatment strategies. Here, we characterize the growth arrest and DNA damage-inducible gene gamma (GADD45g) as a novel tumor suppressor in AML. We show that GADD45g is preferentially silenced in AML, especially in AML with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutations and...

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PMID: 33945602
DOI: 10.1182/blood.2020008229

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