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Article

Memantine suppresses the excitotoxicity but fails to rescue the ataxic phenotype in SCA1 model mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 May 2024

Belozor Olga S, Vasilev Alex, Mileiko Alexandra G, Mosina Lyudmila D, Mikhailov Ilya G, Ox Darius A, Boitsova Elizaveta B, Shuvaev Andrey N, Teschemacher Anja G, Kasparov Sergey, Shuvaev Anton N

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is a debilitating neurodegenerative disorder of the cerebellum and brainstem. Memantine has been proposed as a potential treatment for SCA1. It blocks N-methyl-D-aspartate (NMDA) receptors on neurons, reduces excitotoxicity and decreases neurodegeneration in Alzheimer models. However, in cerebellar neurodegenerative diseases, the potential value of memantine is still unclear....

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Source

Identifiers

PMID: 38574621
DOI: 10.1016/j.biopha.2024.116526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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