Article

Altered calcium signaling in Bergmann glia contributes to Spinocerebellar ataxia type-1

2023-05-09

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by an abnormal expansion of glutamine (Q) encoding CAG repeats in the ATAXIN1 ( ATXN1 ) gene and characterized by progressive cerebellar ataxia, dysarthria, and eventual deterioration of bulbar functions. SCA1 shows severe degeneration of cerebellar Purkinje cells (PCs) and activation of Bergmann glia (BG), a type of cerebellar astroglia...

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Literature Corpus work: 5e0bd839-ad75-5c32-b414-a5fc822484f1
DOI: 10.1101/2023.05.09.539932

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