Article

A chlorzoxazone-baclofen combination improves cerebellar impairment in spinocerebellar ataxia type 1

2020-08-14

Abstract excerpt

<h4>Background</h4> A combination of central muscle relaxants, chlorzoxazone and baclofen (chlorzoxazone-baclofen), has been proposed for treatment of cerebellar symptoms in human spinocerebellar ataxia (SCA). However, central muscle relaxants can worsen balance. The optimal dose for target engagement without toxicity remains unknown. <h4>Objectives</h4> Using the genetically precise Atxn1 154Q/2Q model of SCA1...

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Literature Corpus work: 88ac0ac3-4439-586a-95b7-7bfd08026714
DOI: 10.1101/2020.08.14.251330

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