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Article

Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons.

Neuropathology and applied neurobiology - 1 Feb 2021

Sato Masahiro, Ohta Tomoko, Morikawa Yuri, Konno Ayumu, Hirai Hirokazu, Kurauchi Yuki, Hisatsune Akinori, Katsuki Hiroshi, Seki Takahiro

Abstract excerpt

AIMS: Chaperone-mediated autophagy (CMA) is a pathway involved in the autophagy lysosome protein degradation system. CMA has attracted attention as a contributing factor to neurodegenerative diseases since it participates in the degradation of disease-causing proteins. We previously showed that CMA is generally impaired in cells expressing the proteins causing spinocerebellar ataxias (SCAs). Therefore, we...

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PMID: 32722888
DOI: 10.1111/nan.12649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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