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Article

Cerebellar contribution to the cognitive alterations in SCA1: evidence from mouse models

4 Nov 2019

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by abnormal expansion of glutamine (Q) encoding CAG repeats in the gene Ataxin-1 (ATXN1). Although motor and balance deficits are the core symptoms of SCA1, cognitive decline is also commonly observed in patients. While mutant ATXN1 is expressed throughout the brain, pathological findings reveal severe atrophy of cerebellar cortex in...

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PMID: 31696233
DOI: 10.1093/hmg/ddz265

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