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Immunogenetic Diversity and Cancer Immunotherapy Disparities

4 Apr 2024

Abstract excerpt

SUMMARY: The success of checkpoint blockade cancer immunotherapies has unequivocally confirmed the critical role of T cells in cancer immunity and boosted the development of immunotherapeutic strategies targeting specific antigens on cancer cells. The vast immunogenetic diversity of human leukocyte antigen (HLA) class I alleles across populations is a key factor influencing the advancement of HLA class...

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PMID: 38571423
DOI: 10.1158/2159-8290.cd-23-1536

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