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Article

Genetic mutation of Cep76 results in male infertility due to abnormal sperm tail composition.

Life science alliance - 1 Jun 2024

Houston Brendan J, Merriner D Jo, Stathatos G Gemma, Nguyen Joseph H, O'Connor Anne E, Lopes Alexandra M, Conrad Donald F, Baker Mark, Dunleavy Jessica Em, O'Bryan Moira K

Abstract excerpt

The transition zone is a specialised gate at the base of cilia/flagella, which separates the ciliary compartment from the cytoplasm and strictly regulates protein entry. We identified a potential new regulator of the male germ cell transition zone, CEP76. We demonstrated that CEP76 was involved in the selective entry and incorporation of key proteins required for sperm function and fertility into the ciliary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38570187
DOI: 10.26508/lsa.202302452
PMCID: PMC10992998

Genes

CEP76
AKAP4
DNAH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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