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Article

The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus.

Nature communications - 13 Aug 2021

Zhang Ying, Liu Chao, Wu Bingbing, Li Liansheng, Li Wei, Yuan Li

Abstract excerpt

The sperm head-to-tail coupling apparatus (HTCA) ensures sperm head-tail integrity while defective HTCA causes acephalic spermatozoa, rendering males infertile. Here, we show that CENTLEIN is indispensable for HTCA integrity and function, and that inactivation of CENTLEIN in mice leads to sperm decapitation and male sterility. We demonstrate that CENTLEIN directly interacts with both SUN5 and PMFBP1, two proteins...

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Identifiers

PMID: 34389728
DOI: 10.1038/s41467-021-25227-w
PMCID: PMC8363609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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