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Article

Computational identification of disease models through cross-species phenotype comparison.

Disease models & mechanisms - 1 Jun 2024

Cacheiro Pilar, Pava Diego, Parkinson Helen, VanZanten Maya, Wilson Robert, Gunes Osman, The International Mouse Phenotyping Consortium, Smedley Damian

Abstract excerpt

The use of standardised phenotyping screens to identify abnormal phenotypes in mouse knockouts, together with the use of ontologies to describe such phenotypic features, allows the implementation of an automated and unbiased pipeline to identify new models of disease by performing phenotype comparisons across species. Using data from the International Mouse Phenotyping Consortium (IMPC), approximately half of...

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Identifiers

PMID: 38881316
DOI: 10.1242/dmm.050604
PMCID: PMC11247498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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