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Article

NMR characterization and ligand binding site of the stem-loop 2 motif from the Delta variant of SARS-CoV-2.

RNA (New York, N.Y.) - 17 Jun 2024

Matzel Tobias, Martin Maria Wirtz, Herr Alexander, Wacker Anna, Richter Christian, Sreeramulu Sridhar, Schwalbe Harald

Abstract excerpt

The stem-loop 2 motif (s2m) in SARS-CoV-2 (SCoV-2) is located in the 3'-UTR. Although s2m has been reported to display characteristics of a mobile genomic element that might lead to an evolutionary advantage, its function has remained unknown. The secondary structure of the original SCoV-2 RNA sequence (Wuhan-Hu-1) was determined by NMR in late 2020, delineating the base-pairing pattern and revealing substantial...

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Identifiers

PMID: 38565242
DOI: 10.1261/rna.079902.123
PMCID: PMC11182009

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