Article
The Highly Conserved Stem-Loop II Motif Is Dispensable for SARS-CoV-2.
Journal of virology - 29 Jun 2023
Jiang Hongbing, Joshi Astha, Gan Tianyu, Janowski Andrew B, Fujii Chika, Bricker Traci L, Darling Tamarand L, Harastani Houda H, Seehra Kuljeet, Chen Hongwei, Tahan Stephen, Jung Ana, Febles Binita, Blatter Joshua A, Handley Scott A, Parikh Bijal A, Wang David, Boon Adrianus C M
Abstract excerpt
The stem-loop II motif (s2m) is an RNA structural element that is found in the 3' untranslated region (UTR) of many RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Though the motif was discovered over 25 years ago, its functional significance is unknown. In order to understand the importance of s2m, we created viruses with deletions or mutations of the s2m by reverse genetics...
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