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Article

Effect of the SARS-CoV-2 Delta-associated G15U mutation on the s2m element dimerization and its interactions with miR-1307-3p.

RNA (New York, N.Y.) - 1 Nov 2023

Cunningham Caylee L, Frye Caleb J, Makowski Joseph A, Kensinger Adam H, Shine Morgan, Milback Ella J, Lackey Patrick E, Evanseck Jeffrey D, Mihailescu Mihaela-Rita

Abstract excerpt

The s2m, a highly conserved 41-nt hairpin structure in the SARS-CoV-2 genome, serves as an attractive therapeutic target that may have important roles in the virus life cycle or interactions with the host. However, the conserved s2m in Delta SARS-CoV-2, a previously dominant variant characterized by high infectivity and disease severity, has received relatively less attention than that of the original SARS-CoV-2...

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Identifiers

PMID: 37604684
DOI: 10.1261/rna.079627.123
PMCID: PMC10578481

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